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# Unit 2: Biology
## Cellular Biology
A person contains roughly 100 trillion cells
- Cells are roughly 20 `μm` (micrometre, 10<sup>-6</sup> m), around 250 cells / cm
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|Organization|Usually singlecelled|Often form multicellular organisms|
|Metabolism|May not need oxygen|Usually need oxygen|
## Cellular Organelles
### Business Analogy
| In a business | In a cell |
| ------------- | --------- |
| Building | Cytoplasm & Cytoskeleton |
| Department Head | Organelles |
| Boss | DNA |
| Workers | Ribosomes & Enzymes |
| Waste management | Lysosomes |
| Storage | Vacuoles |
| Powerhouse | Chloroplasts & Mitochondria |
| Security gate | Cell membrane controls entrance and exit from the cell |
| Transportation Department | IMPORT: Cell membranes and vesicles, INTERNAL: Endoplasmic reticulum & vesicles, EXPORT: Golgi apparatus, vesicles, and cell membrane |
## Organelles
### Cell Membrane
- Controls what substances **enter/leave** the cell selectively via various receptors/osmosis
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- `Zygote`: A single-celled organism formed from the fertilization of an egg by a sperm cell, is a totipotent stem cell
- A cell's position in the `gastrula` (outer, middle, inner layer) will determine the fate of the cell, or its potiental.
- Chemical signals from other cells will also determine activated genes that lead to specialisation
- (LOCATION LOCATION LOCAION!)
- (LOCATION LOCATION LOCATION!)
- Specialisation is determined by reading only certain genes
### Stem Cells
- They are an **unspecialized** cell that has the potential to become one of several types of cells.
- **Unspecialized** cells with the potential to become one of several types of cells.
- Can either divide to two stem cells or one stem cell and one specialised cell
- Specialised cells generally do not divide
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- Intestines
- Pancreas makes most digestive enzymes and pumps them in the duodenum
- Absorbs nutrients and water to bloodstream
- Duodenum digests food chemically even more
- Forms and excretes feces
- Contains smooth muscle to continue peristalsis
- Contains plenty of blood vessels for faster nutrient absorption
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## Respiratory system
- Exchanges oxygen gas and carbon dioxide gas between red blood cells and the surrounding air, which is required for cellular respiration
- Diaphragm contracts to lower itself, causing the rib cage to rise, which increases lung volume, which subsequently causes pressure to decrease and air to rush in to the lungs
- Diaphragm relaxes to return everything to its normal position
- Diaphragm relaxes to return everything to its normal position
- Air is warmed and moisted while passing through nasal cavity blood vessels
- Trachea and bronchi are made of rigid cartilage rings
- Prevents airways from closing, similar to a vacuum hose
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- Chance of disease from the vaccine are far lower than chance of death or serious infection from a pathogen
- Vaccines do not cause autism or seizures, but may act as a trigger for the latter due to genetics
## Musculoskeletal system
## Musculoskeletal system
- Maintains **structure**
- **Protects** other systems and cells
- Enables **movement**
- Four types of **connective tissues**: Ligaments, tendons, bones, and cartilage
| **Bone** | **Information** | **Location** |
| :--- | :--- | :--- |
| Clavicle | Collarbone | Collar |
| Humerus | Funny bone | Lower upper arm |
| Femur | Largest bone | Thigh |
| Tibia | One of two bones in lower leg | Front lower leg |
| Vertebrae | Enable spinal movement | Spine |
| Patella | Prevents leg overextension and protects knee join | Kneecap |
### Bones
- Hard and dense
- Bone cells produce minerals (e.g., phosphorus + calcuium) and **collagen**
- Minerals for strength, collagen for flexibility
- Bone marrow produces blood cells
- Contain blood cells
### Joints
- Anywhere where two bones meet
- Types of joints
- Hinge joint (e.g., knee, elbow)
- Ball and socket joint (e.g., Hip, shoulder)
- Fixed (e.g., skull, pelvis)
- `Ligaments` connect bones across joints
- `Cartilage` cushions bone on each side of joint and allows for smooth motion
### Skeletal Muscle
- Made of **striated** muscle fibres of long cells
- Voluntary muscles, receive signals from brain via nerves
- Always come in pairs as **any muscle can only pull, not push**
- Must be attached to two bones in order to move a bone
## Nervous System
- Coordinates body activities
- `Central nervous system`: Brain + spinal cord
- `Peripheral nervous system`: All other nerves connecting everything to spinal cord/brain
- `Neurons` send electric signals down their singular long `axon` branch thing
- They accept signals from `dendrites` on the main cell body
- `Schwann cells` form the `myelin sheath` to insulate and nurture the axon, protecting it from interference
- Neurotransmitters are chemical signals that transmit information between neurons
- Electrical signals tell chemical signals to go to other neurons
- Nerves
- Bundle of axons
- Surrounded with blood vessels and connective tissue
- Nerve signals are short-lived, fast, and targeted towards specific groups of cells
### Disorders
- Parkinson's disease
- Loss of brain neurons that send neurotransmitters to muscles
- Leads to muscular and mental decline
- Multiple sclerosis
- Immune system attacks myelin sheath
- Disruption of neurons' electric signals due to lack of protection
- Causes spasms and loss of muscular control
- Alzheimer's disease
- Protein deposits (plaque) build up in brain tissue
- Leads to memory loss and total system failure
## Endocrine System
- Coordinates organ functions
- `Hormone` chemical signals produced by endocrine glands that, compared to nerve signals, are **long-lasting**, **slower**, and **general**
- Specific hormones bind to specific receptors on specific cell membranes (e.g., mailing lists)
- Hormones travel through the bloodstream
- Hormones either encourage or discourage activity
- Can cause positive or negative feedback loops with glands
| **Endocrine organ** | **Purpose** | **Location** |
| :--- | :--- | :--- |
| Pituitary gland | Controls growth and development | Brain |
| Pancreas | Secretes insulin to ensure sugar in bloodstream is taken in by cells | Attached to duodenum |
| Gonads (ovaries + testes) | Secretes the reproductive hormones testosterone and estrogen, respectively | Lower abdomen |
| Adrenal glands | Control stress response, secrete adrenaline (fight/flight response) | Above kidneys |
### Disorders
- Type 1 diabetes: The pancreas is unable to produce any insulin, resulting in high blood sugar
- Generally caused by genetics
- Type 2 diabetes: The pancreas produces not enough insulin and/or cells are resistant to it, resulting in high blood sugar
- Generally caused by lifestyle choices (e.g., diet)
- Growth disorders (dwarfism/gigantism)
- Caused by poor pituitary and/or hypothalamus function or endocrine gland damage as an adult