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# Unit 2: Biology
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# Unit 2: Biology
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## Cellular Biology
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A person contains roughly 100 trillion cells
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A person contains roughly 100 trillion cells
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- Cells are roughly 20 `μm` (micrometre, 10<sup>-6</sup> m), around 250 cells / cm
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- Cells are roughly 20 `μm` (micrometre, 10<sup>-6</sup> m), around 250 cells / cm
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|Organization|Usually singlecelled|Often form multicellular organisms|
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|Organization|Usually singlecelled|Often form multicellular organisms|
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|Metabolism|May not need oxygen|Usually need oxygen|
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|Metabolism|May not need oxygen|Usually need oxygen|
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## Cellular Organelles
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## Organelles
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### Business Analogy
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| In a business | In a cell |
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| ------------- | --------- |
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| Building | Cytoplasm & Cytoskeleton |
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| Department Head | Organelles |
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| Boss | DNA |
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| Workers | Ribosomes & Enzymes |
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| Waste management | Lysosomes |
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| Storage | Vacuoles |
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| Powerhouse | Chloroplasts & Mitochondria |
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| Security gate | Cell membrane controls entrance and exit from the cell |
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| Transportation Department | IMPORT: Cell membranes and vesicles, INTERNAL: Endoplasmic reticulum & vesicles, EXPORT: Golgi apparatus, vesicles, and cell membrane |
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### Cell Membrane
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### Cell Membrane
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- Controls what substances **enter/leave** the cell selectively via various receptors/osmosis
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- Controls what substances **enter/leave** the cell selectively via various receptors/osmosis
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- `Zygote`: A single-celled organism formed from the fertilization of an egg by a sperm cell, is a totipotent stem cell
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- `Zygote`: A single-celled organism formed from the fertilization of an egg by a sperm cell, is a totipotent stem cell
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- A cell's position in the `gastrula` (outer, middle, inner layer) will determine the fate of the cell, or its potiental.
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- A cell's position in the `gastrula` (outer, middle, inner layer) will determine the fate of the cell, or its potiental.
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- Chemical signals from other cells will also determine activated genes that lead to specialisation
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- Chemical signals from other cells will also determine activated genes that lead to specialisation
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- (LOCATION LOCATION LOCAION!)
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- (LOCATION LOCATION LOCATION!)
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- Specialisation is determined by reading only certain genes
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- Specialisation is determined by reading only certain genes
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### Stem Cells
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### Stem Cells
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- They are an **unspecialized** cell that has the potential to become one of several types of cells.
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- **Unspecialized** cells with the potential to become one of several types of cells.
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- Can either divide to two stem cells or one stem cell and one specialised cell
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- Can either divide to two stem cells or one stem cell and one specialised cell
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- Specialised cells generally do not divide
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- Specialised cells generally do not divide
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@ -355,7 +339,6 @@ A person contains roughly 100 trillion cells
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- Intestines
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- Intestines
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- Pancreas makes most digestive enzymes and pumps them in the duodenum
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- Pancreas makes most digestive enzymes and pumps them in the duodenum
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- Absorbs nutrients and water to bloodstream
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- Absorbs nutrients and water to bloodstream
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- Duodenum digests food chemically even more
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- Forms and excretes feces
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- Forms and excretes feces
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- Contains smooth muscle to continue peristalsis
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- Contains smooth muscle to continue peristalsis
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- Contains plenty of blood vessels for faster nutrient absorption
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- Contains plenty of blood vessels for faster nutrient absorption
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## Respiratory system
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## Respiratory system
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- Exchanges oxygen gas and carbon dioxide gas between red blood cells and the surrounding air, which is required for cellular respiration
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- Exchanges oxygen gas and carbon dioxide gas between red blood cells and the surrounding air, which is required for cellular respiration
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- Diaphragm contracts to lower itself, causing the rib cage to rise, which increases lung volume, which subsequently causes pressure to decrease and air to rush in to the lungs
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- Diaphragm contracts to lower itself, causing the rib cage to rise, which increases lung volume, which subsequently causes pressure to decrease and air to rush in to the lungs
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- Diaphragm relaxes to return everything to its normal position
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- Diaphragm relaxes to return everything to its normal position
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- Air is warmed and moisted while passing through nasal cavity blood vessels
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- Air is warmed and moisted while passing through nasal cavity blood vessels
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- Trachea and bronchi are made of rigid cartilage rings
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- Trachea and bronchi are made of rigid cartilage rings
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- Prevents airways from closing, similar to a vacuum hose
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- Prevents airways from closing, similar to a vacuum hose
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- Vaccines do not cause autism or seizures, but may act as a trigger for the latter due to genetics
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- Vaccines do not cause autism or seizures, but may act as a trigger for the latter due to genetics
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## Musculoskeletal system
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## Musculoskeletal system
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- Maintains **structure**
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- **Protects** other systems and cells
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- Enables **movement**
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- Four types of **connective tissues**: Ligaments, tendons, bones, and cartilage
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| **Bone** | **Information** | **Location** |
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| :--- | :--- | :--- |
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| Clavicle | Collarbone | Collar |
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| Humerus | Funny bone | Lower upper arm |
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| Femur | Largest bone | Thigh |
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| Tibia | One of two bones in lower leg | Front lower leg |
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| Vertebrae | Enable spinal movement | Spine |
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| Patella | Prevents leg overextension and protects knee join | Kneecap |
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### Bones
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- Hard and dense
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- Bone cells produce minerals (e.g., phosphorus + calcuium) and **collagen**
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- Minerals for strength, collagen for flexibility
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- Bone marrow produces blood cells
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- Contain blood cells
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### Joints
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- Anywhere where two bones meet
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- Types of joints
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- Hinge joint (e.g., knee, elbow)
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- Ball and socket joint (e.g., Hip, shoulder)
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- Fixed (e.g., skull, pelvis)
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- `Ligaments` connect bones across joints
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- `Cartilage` cushions bone on each side of joint and allows for smooth motion
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### Skeletal Muscle
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- Made of **striated** muscle fibres of long cells
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- Voluntary muscles, receive signals from brain via nerves
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- Always come in pairs as **any muscle can only pull, not push**
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- Must be attached to two bones in order to move a bone
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## Nervous System
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- Coordinates body activities
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- `Central nervous system`: Brain + spinal cord
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- `Peripheral nervous system`: All other nerves connecting everything to spinal cord/brain
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- `Neurons` send electric signals down their singular long `axon` branch thing
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- They accept signals from `dendrites` on the main cell body
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- `Schwann cells` form the `myelin sheath` to insulate and nurture the axon, protecting it from interference
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- Neurotransmitters are chemical signals that transmit information between neurons
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- Electrical signals tell chemical signals to go to other neurons
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- Nerves
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- Bundle of axons
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- Surrounded with blood vessels and connective tissue
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- Nerve signals are short-lived, fast, and targeted towards specific groups of cells
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### Disorders
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- Parkinson's disease
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- Loss of brain neurons that send neurotransmitters to muscles
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- Leads to muscular and mental decline
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- Multiple sclerosis
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- Immune system attacks myelin sheath
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- Disruption of neurons' electric signals due to lack of protection
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- Causes spasms and loss of muscular control
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- Alzheimer's disease
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- Protein deposits (plaque) build up in brain tissue
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- Leads to memory loss and total system failure
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## Endocrine System
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- Coordinates organ functions
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- `Hormone` chemical signals produced by endocrine glands that, compared to nerve signals, are **long-lasting**, **slower**, and **general**
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- Specific hormones bind to specific receptors on specific cell membranes (e.g., mailing lists)
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- Hormones travel through the bloodstream
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- Hormones either encourage or discourage activity
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- Can cause positive or negative feedback loops with glands
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| **Endocrine organ** | **Purpose** | **Location** |
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| :--- | :--- | :--- |
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| Pituitary gland | Controls growth and development | Brain |
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| Pancreas | Secretes insulin to ensure sugar in bloodstream is taken in by cells | Attached to duodenum |
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| Gonads (ovaries + testes) | Secretes the reproductive hormones testosterone and estrogen, respectively | Lower abdomen |
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| Adrenal glands | Control stress response, secrete adrenaline (fight/flight response) | Above kidneys |
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### Disorders
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- Type 1 diabetes: The pancreas is unable to produce any insulin, resulting in high blood sugar
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- Generally caused by genetics
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- Type 2 diabetes: The pancreas produces not enough insulin and/or cells are resistant to it, resulting in high blood sugar
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- Generally caused by lifestyle choices (e.g., diet)
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- Growth disorders (dwarfism/gigantism)
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- Caused by poor pituitary and/or hypothalamus function or endocrine gland damage as an adult
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